Gastro Intestinal Tract Testing

Complete Digestive Stool Analysis (CDSA)

The Complete Digestive Stool Analysis (CDSA) is a functional test that provides an overview of the components of digestion, absorption, intestinal function and microbial flora, as well as identifying pathogenic bacteria, parasites and yeasts.

The CDSA is a non-invasive test providing invaluable information for the patient and practitioner in terms of understanding the role of poor digestive function in disease states.

Poor digestive function and imbalanced gut flora may play a crucial role in the underlying cause of a number of health conditions. Symptoms such as constipation, diarrhoea, flatulence, bloating, abdominal discomfort and bad breath are all indicative of poor gut function.

Functional Liver Detoxification Profile (FLDP)

The Functional Liver Detoxification Profile (FLDP) challenges the liver's Phase I and Phase II detoxification capacity with low doses of Caffeine, Aspirin and Paracetamol. Saliva and urine specimens, collected at timed intervals, are then analysed for metabolites of the three compounds to determine the efficiency of the liver in their conversion and clearance from the body.

Phase I reactions utilise the Cytochrome P450 mixed function oxidase (MFO) enzymes. The primary function of these enzymes is to oxidise endogenous and exogenous chemicals for excretion. This provides a mechanism of protection from a wide variety of toxins.

Phase II reactions involve the addition of a small polar molecule to the substance, a conjugation step that may or may not be preceded by Phase I. Several types of conjugation reactions occur in the body, including glutathionation, sulphation, glucuronidation, glycination.

The results of an FLDP will support accurate identification of the individual's detoxification profile and assist in the direction of treatment. The FLDP may particularly provide valuable information in the management of patients who suffer from food allergies, multiple chemical sensitivities, chronic fatigue syndrome, "leaky gut" and hormonal imbalance eg. premenstrual syndrome and menopausal symptoms.

Helicobacter pylori Stool Antigen (HpSA)

Helicobacter pylori (H.pylori) are the most common bacteria to infect humans. They are found in the gastric mucosa and the mouth and transmitted orally through saliva. H.pylori infection may cause symptoms such as gastritis, halitosis, heart burn and abdominal cramping and is known to be a major cause of gastric ulcers.

The Helicobacter pylori Stool Antigen test (HpSA) is an enzyme immunoassay which detects H.pylori antigens present in human stool samples. This faecal-antigen test overcomes most of the limitations of existing tests for H.pylori. HpSA has a 95% correlation with reference methods such as endoscopy, histology and urea breath test.

This is a non-invasive test which detects active infection. It is recommended that patients are retested four weeks after completion of eradication therapy.

Intestinal Permeability (IP)

The Intestinal Permeability (IP) test, also referred to as a "leaky gut" test, is a precise and non-invasive method for assessing gastrointestinal mucosal integrity. Damage to the lining of the gastrointestinal tract (small and large intestine) is common in people with conditions such as food sensitivity and food allergy, irritable bowel syndrome, Crohn's disease, arthritis, coeliac disease and dermatological conditions such as eczema, psoriasis and acne.

The lining of the gut wall is often subjected to a wide variety of insults from substances such as alcohol, caffeine, spices, medicines and environmental chemicals. The impact of chronic stress may also affect the permeability of the gut wall over time. Correcting the altered permeability may have an immediate effect on the relief of symptoms and facilitate the gradual improvement in the underlying condition.

The IP is a challenge test using Lactulose and Mannitol.

3 Day Parasitology (3DP)

This test is designed to help identify parasitic infection in the human gastrointestinal tract. Symptoms of parasitic infection include acute watery diarrhoea, nausea, abdominal pain and cramps, fatigue and weight loss.

The most appropriate test for the diagnosis and treatment of parasites requires the examination of three stool samples collected over three consecutive days. The parasites commonly detected include Blastocystis hominis, Dientamoeba fragilis, Giardia lamblia, Endomilax nana, Entamoeba histolytica and Cryptosporidium parvum. If any other parasites are detected they will also be reported.

Secretory IgA (sIgA)

Secretory immunoglobulin A (sIgA) found in saliva, gastric fluids, plasma and the mucous membranes of the body, provides the main immunological defence of mucosal surfaces against pathogenic invasion. It is thought to be representative of the functional status of the entire mucosal immune system.

Stress has a major impact on the output of sIgA and maintaining a high daily production is essential for an adaptive immune response. It is thought that sIgA may provide a link between gut-related health conditions and systemic illness and is usually associated with altered intestinal permeability.

Investigation of salivary sIgA is recommended in food sensitivity, allergy, atopic conditions such as asthma and eczema, inflammatory bowel disease, irritable bowel syndrome and chronic infection.

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